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(Diagram: In Acute Myocardial Infarction obstruction
of coronary artery leads to coagulative necrosis of the myocardium in
the ischemic area. The deeply eosinophilic necrotic cells have lost
their nuclei and cross striation).
Visit:
Necrosis
;
Myocardial Infarction
In coagulative
necrosis, denaturation of intra-cytoplasmic protein is the
dominant process.
The dead tissue
becomes firm and slightly swollen.
The protein
molecules within the cytoplasm becomes unfolded and this renders the
tissue both more opaque than normal and more reactive to certain dyes
such as eosin.
Microscopically, the cells show the signs of nuclear death , but the
most noteworthy feature is the
retention
of the general architectural pattern of the tissue,
despite the death of its constituent elements.
Coagulative
necrosis occurs typically in ischemic injury, such as may occur in the
heart and kidney.
However, for
reasons which are not clear, ischemic injury in the central nervous
system leads to necrosis dominated by enzymatic digestion and
liquefaction of the dead tissue.

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