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(Diagram: In Acute Myocardial Infarction obstruction of coronary artery leads to coagulative necrosis of the myocardium in the ischemic area. The deeply eosinophilic necrotic cells have lost their nuclei and cross striation).
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Necrosis In coagulative necrosis, denaturation of intra-cytoplasmic protein is the dominant process. The dead tissue becomes firm and slightly swollen. The protein molecules within the cytoplasm becomes unfolded and this renders the tissue both more opaque than normal and more reactive to certain dyes such as eosin.
Microscopically, the cells show the signs of nuclear death , but the most noteworthy feature is the retention of the general architectural pattern of the tissue, despite the death of its constituent elements. Coagulative necrosis occurs typically in ischemic injury, such as may occur in the heart and kidney. However, for reasons which are not clear, ischemic injury in the central nervous system leads to necrosis dominated by enzymatic digestion and liquefaction of the dead tissue.
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