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(Diagram: Fibrinoid necrosis in a medium-sized artery. The muscular media contains sharply demarcated, homogeneous, deeply eosinophilic areas of necrosis).
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Necrosis
There is an alteration of blood vessels known as fibrinoid necrosis. In this case, the proximity of the blood allows insudation and accumulation of plasma proteins that cause the injured vessels to stain intensely eosinophilic, hence the name fibrinoid necrosis. The term is something of a misnomer, however, because the eosinophilia of the accumulated plasma proteins obscures the underlying alterations in the blood vessel, making it difficult to determine whether there is truly any necrosis of the vascular wall.
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