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Pulmonary Pathology Online

Anatomy and Histology of the Normal Lung and Airways

Examination of pulmonary and pleural biopsies

Useful chromatic and immunostains in pulmonary pathology

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Histopathological reporting of pulmonary parenchymal biopsies

Histopathological reporting of pulmonary biopsies in cases of Idiopathic Pulmonary Fibrosis

Closed pleural biopsy for neoplasm or inflammatory lesions ; Open pleural biopsy and pneumonectomy or pleural stripping

Anatomical Distribution of Pulmonary Disease

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Desquamative interstitial pneumonia

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Visit: Inflammation ; Inflammatory cells in acute and chronic inflammation ; Acute Inflammation ; Chemical Mediators ;Chronic Inflammation ; Wound Healing .

Types of acute inflammation:

1. Catarrhal type- Mild inflammation in mucous membrane and is characterized by copious outpouring of mucus along with desquamated epithelial cells and a few leucocytes. Example: Common cold, catarrhal appendicitis etc.

2. Serous type- Mild inflammation in serous surface such as pleural cavity joint cavity etc with accumulation of low protein containing fluid (effusion). Example: Tuberculous pleurisy. It is also seen due to repeated mild trauma. Example: Common blisters.

3. Fibrinous type- Characterized by outpouring of exudates with high protein and less volume. Commonly seen in serous surface such as pleura, peritoneum, pericardium. Two  contiguous surfaces covered in fibrin tend to stick together and  if not lysed scar tissue is formed with permanent loss of function - Example:  Adhesive and constrictive pericarditis. Lobar Pneumonia due to Streptococcus pneumoniae is associated  with massive fibrinous exudates in the lung alveoli. Visit: Pericardial Disease

               

Lobar pneumonia shows massive fibrinous inflammatory exudates in alveoli.

4. Membranous type- Fibrinous inflammation in which network of fibrin entangling inflammatory cells and bacteria forms pseudo-membrane. Example: Diphtheria , Bacillary dysentery.  

            

Pseudomembranous inflammation in diphtheria showing network of fibrin entangling inflammatory cells. Bacteria forming pseudo-membrane (left).

5. Suppurative or purulent type-  Usually caused by  pyogenic bacteria and is characterized by pus formation Example: Abscess.

                                      Abscess:  

Abscess is the localized collection of pus, commonly seen solid block of tissue - Example: dermis, liver, kidney, brain etc. Pus consists of partly or completely liquified dead tissue mixed with dead or dying neutrophils and living or dead bacteria,

           

Pyemic abscess in myocardium. Abscess containing necrotic cell debris, colonies of bacteria, and large number of neutrophils, many of them degenerate.Myocardium is on the right.    

Microscopic feature:

Central purulent zone is surrounded from inside outwards by, pus cells, living neutrophils and granulation tissue known as  pyogenic membrane. This last layer represents the repair process and serves as a barrier to the spread of inflammation. It also prevents the discharge of pus from the abscess without which healing cannot occur. When pus is drained the granulation tissue proliferates to replace the necrotic tissues and repair is done.

6. Phlegmonous type- (Phlegmon means fire): Characterized by woody hardness of the inflamed area due to low resistance  of the body and high virulence of the bacteria - Example: Erysipelas, pelvic cellulites etc.

                  

 

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August 2008

Introduction of Pathology

An outline of Diagnostic Techniques available in Pathology

Cellular Injury

Diagram showing Structural Changes in Reversible and Irreversible Cell Injury

Autolysis

Heterolysis

Necrosis

Coagulation (Coagulative) necrosis

Caseative (Caseous) necrosis

Liquefaction necrosis

Fat necrosis

Fibrinoid necrosis

Apoptosis

Gangrene

Pathologic Calcification

Hyaline Change

Atrophy

Hypertrophy

Hyperplasia

Metaplasia

Aplasia

Hypoplasia

Circulatory Anatomy, Physiology and Regulation

Normal Fluid Balance

Edema

Diagram showing Capillary System and Mechanisms  of Edema Formation

Morphology of Edema

Hyperemia and Congestion

Hemostasis and Thrombosis

Embolism

Fat Embolism

Air Embolism

Decompression Sickness

Amniotic Fluid Embolism

Cellular Accumulations

Accumulation of Glycogen, complex lipids and carbohydrates


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