Custom Search


Pathology Photo of the Day -

MICE - A matter of Heart

Mesothelial/monocytic incidental cardiac excrescence (MICE)

Dr Sampurna Roy  MD


                     Home       Previous Posts



Mesothelial/monocytic incidental cardiac excrescence (MICE) is a very rare benign lesion found incidentally in the left cardiac chambers and on valve surfaces, especially during aortic and mitral valve surgery or in endomyocardial biopsy specimens.

Mesothelial/monocytic incidental cardiac excrescence" was introduced by Veinot et al in 1994.


This pseudo-tumor histologically shows solid cell clusters within a meshwork of  fibrin. 

The lesion is composed of a mixture of histiocytes, mesothelial cells, fibrin, adipocytes, and inflammatory cells without a vascular network or supporting stroma.

The cells are round to polygonal with eosinophilic cytoplasm, sometimes the cells have a foamy or vacuolated appearance with distinct cell borders. These cells have a histiocytoid or epithelioid like appearance.

In areas the tumour may show gland-like or papillary structures of small cuboidal cells.

Immunohistochemistry reveals the biphasic nature of the lesion with cytokeratin positivity of the cuboidal cells and CD68 (KP-1) positivity of the histiocytes.

These lesions should not be mistaken for a primary or metastatic malignant tumour.


Further reading:

Mesothelial/monocytic incidental cardiac excrescences: cardiac MICE.

Cardiac MICE--tumor or thrombus?

A case of mesothelial/monocytic incidental cardiac excrescence and literature review.

Mesothelial/monocytic incidental cardiac excrescence: a case report and review of literature.

Cardiac mesothelial/monocytic-incidental-excrescence: more than an artifactual lesion?

Metastatic adenocarcinoma involving a mesothelial/monocytic incidental cardiac excrescence (cardiac MICE)

                     Home       Previous Posts



Dr  Sampurna Roy  MD

Consultant Histopathologist (Kolkata - India)






Infectious Disease Online


Pathology Quiz Online 


Paediatric Pathology Online


Pancreatic Pathology Online




Endocrine Pathology Online


Eye Pathology Online


Ear Pathology Online


Cardiac Path Online


Pulmonary Pathology Online


Lung Tumour Online




Nutritional Pathology Online


Environmental Pathology Online


Soft Tissue Tumour Online


GI Path Online-India


Gallbladder Pathology Online


E-book - History of Medicine  


Microscope - Seeing the Unseen





Privacy Policy  

Advertising Policy

Copyright 2017