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MICE - A matter of Heart

Mesothelial/monocytic incidental cardiac excrescence (MICE)

Dr Sampurna Roy  MD

 

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Mesothelial/monocytic incidental cardiac excrescence (MICE) is a very rare benign lesion found incidentally in the left cardiac chambers and on valve surfaces, especially during aortic and mitral valve surgery or in endomyocardial biopsy specimens.

Mesothelial/monocytic incidental cardiac excrescence" was introduced by Veinot et al in 1994.

 

This pseudo-tumor histologically shows solid cell clusters within a meshwork of  fibrin. 

The lesion is composed of a mixture of histiocytes, mesothelial cells, fibrin, adipocytes, and inflammatory cells without a vascular network or supporting stroma.

The cells are round to polygonal with eosinophilic cytoplasm, sometimes the cells have a foamy or vacuolated appearance with distinct cell borders. These cells have a histiocytoid or epithelioid like appearance.

In areas the tumour may show gland-like or papillary structures of small cuboidal cells.

Immunohistochemistry reveals the biphasic nature of the lesion with cytokeratin positivity of the cuboidal cells and CD68 (KP-1) positivity of the histiocytes.

These lesions should not be mistaken for a primary or metastatic malignant tumour.

 

Further reading:

Mesothelial/monocytic incidental cardiac excrescences: cardiac MICE.

Cardiac MICE--tumor or thrombus?

A case of mesothelial/monocytic incidental cardiac excrescence and literature review.

Mesothelial/monocytic incidental cardiac excrescence: a case report and review of literature.

Cardiac mesothelial/monocytic-incidental-excrescence: more than an artifactual lesion?

Metastatic adenocarcinoma involving a mesothelial/monocytic incidental cardiac excrescence (cardiac MICE)

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Dr  Sampurna Roy  MD

Consultant Histopathologist (Kolkata - India)

 

 


 

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