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Pathology Photo of the Day -

Blueberry Muffin is not for your Baby.

Blueberry Muffin Syndrome -

Dr Sampurna Roy MD                    May 2016  


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Blueberry Muffin Baby is a rare neonatal cutaneous syndrome characterized by purpuric lesions reflective of extramedullary hematopoiesis.

The blueberry muffin morphology presents as non-blanching, violaceous, magenta-colored macules, papules, nodules and plaque. These are usually 2 to 8mm in diameter.

The lesions are usually generalized but more commonly present on the trunk, head, and neck.

Many causes are known like congenital infections, vascular lesions, malignancy, systemic diseases and hematologic disorders.

- Infectious Diseases -  (Infectious Disease Online)

Cytomegalovirus  Inclusion

Eruption may be associated with Cytomegalovirus, Rubella, Toxoplasmosis, Herpes virus, Parvovirus, Coxackievirus and Epstein-Barr virus and Syphilis.

Spherocytes in Hereditary Spherocytosis

- Hematologic disorder - Hereditary Spherocytosis, alloimmunization, fetomaternal transfusion, ABO blood type incompatibility, Rh incompatibility, Twin-to-twin-transfusion.


- Vascular Lesions - Multiple Hemangiomas and Glomangiomas, Blue rubber bleb nevus syndrome

- Neoplastic Lesions - Congenital leukemia, Neuroblastoma, Congenital rhabdomyosarcome, Hemangiopericytomas, /myofibromatosis.

Langerhans cell histiocytosis

- Systemic Lesions - Langerhans cell histiocytosis and Lupus.


Further reading:

Neonatal violaceous skin lesions: expanding the differential of the "blueberry muffin baby".

Benign transient blueberry muffin baby.

Langerhans cell histiocytosis presenting as blueberry muffin baby.

Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis.

Blueberry muffin baby. A rare presentation of congenital cytomegalovirus infection

Blueberry Muffin Baby and Langerhans' congenital cell histiocytosis.

Blueberry muffin baby: a pictoral differential diagnosis.

Blueberry muffin baby: the pathogenesis of cutaneous extramedullary hematopoiesis.


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Dr  Sampurna Roy  MD

Consultant Histopathologist (Kolkata - India)








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