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Pathology Cartoon of the Day -

Pathologist and a Catchy Acronym:

Progressive outer retinal necrosis (PORN) syndrome

 

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The Acronym -

P = Progressive

O = Outer

R = Retinal

N = Necrosis

 

Progressive outer retinal necrosis (PORN) syndrome is a form of the Varicella zoster virus (VZV) chorioretinitis found  in patients with advanced acquired immunodeficiency syndrome (AIDS). It is an aggressive form of necrotising inflammation which may also affect patients who are severely immune compromised as a result of chemotherapy.  PORN may be associated Cytomegalovirus infection.

Diagram showing extensive intraretinal haemorrhage and retinal atrophy and edema.

In this article the authors questioned the name of this disease. Histological findings indicated that the site of initial necrosis was the inner retina rather than the outer retina. Why would the ophthalmoscopic appearance of this entity give the impression that the early involvement occurs in the outer retina? (Progressive outer retinal necrosis (PORN): a catchy acronym but is the anatomy correct? The salient observation of Lorenz E. Zimmerman, MD. )

Prompt diagnosis and treatment of PORN is necessary to prevent extensive retinal damage and to preserve vision.

 

Further reading:

Progressive outer retinal necrosis (PORN): a catchy acronym but is the anatomy correct? The salient observation of Lorenz E. Zimmerman, MD.

Another case of PORN (bilateral progressive outer retinal necrosis) after allogeneic stem cell transplantation.

Varicella zoster virus (VZV)-related progressive outer retinal necrosis (PORN) after allogeneic stem cell transplantation.

Cytomegalovirus implicated in a case of progressive outer retinal necrosis (PORN).

Progressive outer retinal necrosis syndrome: a comprehensive review of its clinical presentation, relationship to immune system status, and management.

Progressive outer retinal necrosis: a missed diagnosis and a blind, young woman.

Clinical features, management and outcomes of progressive outer retinal necrosis (PORN) in southern Thailand.

 

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Dr  Sampurna Roy  MD

Consultant Histopathologist (Kolkata - India)

 

 


 

 

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