|"Sugary Urine" the subtle killer-
Devastating Complications of Diabetes Mellitus
mellitus is a global health problem that results in multiorgan
to high morbidity
It is regarded as one of the most serious pandemics affecting all societies today.
Some of the major long term complications have been discussed in this post.
Coronary arteriosclerosis in Diabetes Mellitus
Gangrene and ulceration of the foot
Diabetes mellitus accelerates the development of arteriosclerosis with the resultant earlier onset of coronary arteriosclerosis and atherosclerosis in general.
The arteriosclerotic process also involves vessels to the lower extremity with resultant production of gangrene of the toes and feet.
The precipitating causes of gangrene of the lower extremities are usually mechanical, thermal, or chemical trauma resulting in ulceration, infection, and subsequent gangrene.
Comparison of dermal capillaries of the toes amputated from diabetic and nondiabetic persons indicates that thickening of basement membrane of the capillaries is limited to the diabetic group.
Pronounced thickening in the basement membranes of the capillaries in diabetic patients may play some role in the complication of the vascular insufficiency of the lower extremities, possibly by interference with nutrition and response of tissues to injury.
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