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Introduction of Pathology

An outline of Diagnostic Techniques available in Pathology

 I- Cell Injury and Death:

Cellular Injury

Diagram showing Structural Changes in Reversible and Irreversible Cell Injury

Autolysis

Heterolysis

Necrosis

Coagulation (Coagulative) necrosis

Caseative (Caseous) necrosis

Liquefaction necrosis

Fat necrosis

Fibrinoid necrosis

Apoptosis

Gangrene

Hyaline Change

 2- Adaptation :

 Adaptation is the structural and functional changes in cells and tissues to accommodate itself to the changing environment and extra-cellular stress or injury.

Atrophy

Hypertrophy

Hyperplasia

Metaplasia

Aplasia

Hypoplasia

 3- Cellular Accumulations 

When injury is sublethal and sustained, cells and tissues  tend to accumulate substances in abnormal quantities.

Accumulation of Glycogen, complex lipids and carbohydrates

Pigments

Melanin

Pigments derived from Hemoproteins

Hemosiderin and Hemosiderosis

Primary Hemochromatosis

Hematin

Bilirubin

Lipofuscin

Mineral Dusts

Silica

Urate

Amyloid

Pathologic Calcification

4- Inflammation

Inflammatory cells in acute and chronic inflammation

Acute Inflammation

Types of Acute Inflammation

Chemical Mediators

Chronic Inflammation

5-  Wound Healing

6- Hemodynamic Disorders of  Perfusion :

Hemodynamic disorders are those diseases that disturb perfusion and result in organ and cellular injury.

Circulatory Anatomy, Physiology and Regulation

Normal Fluid Balance

Edema

Morphology of Edema

Diagram showing Capillary System and Mechanisms of Edema Formation

Hyperemia and Congestion

Hemostasis and Thrombosis

Embolism

Fat Embolism

Air Embolism

Decompression Sickness

Amniotic Fluid Embolism  

Diagram showing Sources of Arterial Emboli

Diagram showing Sources of Venous Emboli

Infarction

Diagram showing common sites of Systemic Infarction  from Arterial Emboli

Shock

Pathology of Shock

Diagram showing Complications of Shock

Hemorrhage

7- Genetic Disorders

Tay-Sachs disease

Niemann-Pick Disease

Gaucher's Disease

Mucopolysaccharidoses

Glycogen Storage Diseases ( Part I )

Glycogen Storage Diseases ( Part II )

Alkaptonuria

Neurofibromatosis

Cytogenetic disorders involving autosomes:

Down Syndromie (Trisomy 21)

Edward Syndrome (Trisomy 18)

Patau Syndrome (Trisomy 13)

Chromosome 22q11 Deletion Syndrome: (Also known as DiGeorge or Velo-Cardio-Facial Syndrome).

Klinefelter syndrome

Diagram showing clinical features of Klinefelter syndrome

Microscopic Image of Testis in Klinefelter Syndrome.

XYY syndrome

Turner's Syndrome

Diagram showing clinical features of Turner's Syndrome

True Hermaphroditism

Pseudohermaphrodites

Single Gene Disorders with Nonclassic Inheritance:

Triplet Repeat Mutations (Fragile X Syndrome)

Mutations in Mitochondrial Genes (Leber Hereditary Optic Neuropathy)

Genomic Imprinting (Prader-Willi and Angelman  Syndromes)

Gonadal Mosaicism

Diagnosis of Genetic Diseases


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